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Are the relationships between mental health issues and being left-behind gendered in China
BACKGROUND: While most existing studies reveal left-behind children (LBC) are prone to suffering from mental health issues, some other literature fails to develop a statistical significance between being left-behind and facing...
The HAVEN study-hydroxychloroquine in ANCA vasculitis evaluation-a multicentre, randomised, double-blind, placebo-controlled trial
Annastazia E Learoyd, Lauren Arnold, Fiona Reid, Nicholas Beckley-Hoelscher, Alina Casian, Shirish Sangle, Neil Morton, Louise Nel, Angela Cape, Susan John, Sangmi Kim, Dharshene Shivapatham, Raashid Luqmani, David Jayne, James Galloway, Abdel Douiri, David D'Cruz
Apr 17, 2023
Background
Patients with non-severe ANCA-associated vasculitis (AAV) are often prescribed immunosuppressive medications that are associated with severe side effects and a reduced quality of life. There is an unmet need...
AAV Vasculitis Hydroxychloroquine Prednisolone ANCA Auto-immune conditions Humans Immunosuppressive Agents Antibodies Antineutrophil Cytoplasmic Treatment Outcome Double-Blind Method Quality of life Multicenter Studies as Topic Randomized Controlled Trials as Topic Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis covid-19 SARS-CoV-2
Published by: Trials
A randomised study of rituximab and belimumab sequential therapy in PR3 ANCA-associated vasculitis (COMBIVAS)
Mark E McClure, Seerapani Gopaluni, James Wason, Robert B Henderson, Andre van Maurik, Caroline C O Savage, Charles D Pusey, Alan D Salama, Paul A Lyons, Jacinta Lee, Kim Mynard, David R Jayne, Rachel B Jones
Apr 11, 2023
Background
Sequential B cell-targeted immunotherapy with BAFF antagonism (belimumab) and B cell depletion (rituximab) may enhance B cell targeting in ANCA-associated vasculitis (AAV) through several...
Vasculitis Rituximab belimumab ANCA Humans Immunosuppressive Agents Antibodies Antineutrophil Cytoplasmic Treatment Outcome Proteomics Randomized Controlled Trials as Topic Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Published by: Trials
The COSI trial
Camilla Rosan, Kim Alyousefi-van Dijk, Zoe Darwin, Daphne Babalis, Victoria Cornelius, Rachel Phillips, Lani Richards, Hannah Wright, Steve Pilling, Pasco Fearon, Elena Pizzo, Peter Fonagy
Apr 13, 2023
Background
Perinatal mental health difficulties affect up to 27% of birthing parents during pregnancy and the first postnatal year, and if untreated are associated with difficulties in bonding and long-term adverse...
Child Development randomised controlled trial Perinatal mental health Child Attachment Circle Of Security-parenting Parent-infant Bonding Humans Single-Blind Method Parenting Community Mental Health Services Pregnancy Quality of life Child Cost-Benefit Analysis England Female Multicenter Studies as Topic Randomized Controlled Trials as Topic
Published by: Trials
Incomplete reporting of complex interventions
Reporting of intervention research has been inadequate for many years. The development and promotion of freely available checklists aims to address this problem by providing researchers with a list of items that require...
reproducibility complex interventions Research Integrity Journal Editors Submission Guidelines Reporting Checklists Humans Publishing Randomized Controlled Trials as Topic Checklist
Published by: Trials